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Ovarian hyperstimulation syndrome. A new look at an old problem
Aleksei Petrovich Petrenko1,2, Camil Castelo-Branco1, Dmitrij Vasilevich Marshalov3
1a Faculty of Medicine , Institut Clinic of Gynecology, Obstetrics and Neonatology, University of Barcelona, Hospital Clinic-Institut d´Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
Summary
Severe ovarian hyperstimulation syndrome (OHSS) management can be informed by intra-abdominal hypertension (IAH) principles. OHSS and IAH share similar pathophysiology, clinical presentation, and organ dysfunction, guiding treatment strategies.
Area of Science:
- Reproductive Endocrinology
- Critical Care Medicine
- Gastroenterology
Background:
- Ovarian hyperstimulation syndrome (OHSS) is a serious complication of assisted reproductive technologies.
- Severe OHSS presents with significant morbidity and requires careful management.
- Intra-abdominal hypertension (IAH) shares pathophysiological similarities with severe OHSS.
Observation:
- A systematic literature review evaluated OHSS management, focusing on etiology, pathogenesis, and outcomes.
- The review assessed the role of IAH in severe OHSS development and complications.
- Clinical trials, meta-analyses, case reports, and reviews were analyzed using MEDLINE, PubMed, Embase, and the Cochrane Library.
Findings:
- Severe OHSS and IAH exhibit nearly identical pathophysiology and clinical manifestations, including the classic triad of respiratory compromise, reduced venous return, and impaired organ perfusion.
- The management principles for IAH syndrome may be applicable to severe OHSS cases.
- Recommendations for OHSS management and insights into its clinical complaints were provided.
Implications:
- Understanding the parallels between OHSS and IAH can refine severe OHSS treatment protocols.
- Applying IAH management strategies may improve outcomes for patients with severe OHSS.
- This review offers valuable guidance for clinicians managing OHSS and related complications.
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