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Periostin and Inflammatory Disease: Implications for Chronic Rhinosinusitis
Ashton E Lehmann1,2, George A Scangas1,2, Regan W Bergmark1,2
11 Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
Summary
Periostin, an extracellular matrix protein, shows promise as a biomarker for diagnosing and treating chronic rhinosinusitis. Further research highlights its potential role in sinonasal diseases.
Area of Science:
- Biochemistry
- Immunology
- Otorhinolaryngology
Background:
- Chronic rhinosinusitis (CRS) is a prevalent condition with significant clinical and societal impact.
- Current CRS treatment is limited by the lack of effective biomarkers for diagnosis and management.
- Periostin, an extracellular matrix protein, is implicated in various pathologies.
Purpose of the Study:
- To comprehensively review the emerging role of periostin in chronic rhinosinusitis (CRS).
- To explore periostin's potential as a key component in CRS development, diagnosis, and treatment.
- To evaluate periostin as a potential biomarker and therapeutic target for sinonasal diseases.
Main Methods:
- A state-of-the-art literature review was conducted.
- Searches targeted English-language studies on periostin in cardiopulmonary, neoplastic, and inflammatory diseases.
- Emphasis was placed on recent advances in periostin research related to chronic rhinosinusitis.
Main Results:
- Periostin upregulation is observed in chronic rhinosinusitis.
- This suggests a potential role for periostin in sinonasal diseases, similar to its role in other pathologies.
- Periostin is emerging as a novel biomarker and therapeutic target in various human diseases.
Conclusions:
- Periostin is likely to serve as a biomarker for chronic rhinosinusitis.
- Periostin presents a novel therapeutic target for future treatments in patients with sinonasal disease.
- Further investigation into periostin's role in CRS is warranted.
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