Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator

Systems for magnetic resonance (MR-) guided radiotherapy enable daily MR imaging of cancer patients during treatment, which is of interest for treatment response monitoring and biomarker discovery using quantitative MRI (qMRI). Here, the performance of a 1.5 T MR-linac regarding qMRI was assessed on phantoms. Additionally, we show the feasibility of qMRI in a prostate cancer patient on this system for the first time.

Four 1.5 T MR-linac systems from four institutes were included in this study. T₁ and T₂ relaxation times, and apparent diffusion coefficient (ADC) maps, as well as dynamic contrast enhanced (DCE) images were acquired. Bland-Altman statistics were used, and accuracy, repeatability, and reproducibility were determined.

Median accuracy for T₁ ranged over the four systems from 2.7 to 14.3%, for T₂ from 10.4 to 14.1%, and for ADC from 1.9 to 2.7%. For DCE images, the accuracy ranged from 12.8 to 35.8% for a gadolinium concentration of 0.5 mM and deteriorated for higher concentrations. Median short-term repeatability for T₁ ranged from 0.6 to 5.1%, for T₂ from 0.4 to 1.2%, and for ADC from 1.3 to 2.2%. DCE acquisitions showed a coefficient of variation of 0.1-0.6% in the signal intensity. Long-term repeatability was 1.8% for T₁, 1.4% for T₂, 1.7% for ADC, and 17.9% for DCE. Reproducibility was 11.2% for T₁, 2.9% for T₂, 2.2% for ADC, and 18.4% for DCE.

These results indicate that qMRI on the Unity MR-linac is feasible, accurate, and repeatable which is promising for treatment response monitoring and treatment plan adaptation based on daily qMRI.