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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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Serum Calcification Propensity and Coronary Artery Calcification Among Patients With CKD: The CRIC (Chronic Renal

Joshua D Bundy1, Xuan Cai2, Julia J Scialla3

  • 1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|April 3, 2019
PubMed

Insights

Higher serum calcification propensity, measured by T50, is linked to more severe coronary artery calcification (CAC) and its progression in chronic kidney disease (CKD) patients. This finding aids in understanding cardiovascular risks in CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Coronary artery calcification (CAC) is common in chronic kidney disease (CKD) and predicts cardiovascular events.
  • A novel serum measure of calcification propensity may offer insights into CAC development in CKD.

Purpose of the Study:

  • To investigate the association between serum calcification propensity (T50) and CAC in patients with CKD stages 2-4.
  • To determine if T50 predicts CAC severity, incidence, and progression.

Main Methods:

  • Prospective cohort study of 1,274 participants from the Chronic Renal Insufficiency Cohort (CRIC) Study.
  • Serum calcification propensity quantified as transformation time (T50).
  • Multivariable-adjusted generalized linear models used to analyze CAC prevalence, severity, incidence, and progression.

Main Results:

  • Higher calcification propensity (lower T50) was associated with greater CAC severity (21% increase per 1-SD lower T50).
  • Higher calcification propensity was associated with a 28% higher risk of CAC progression over 3 years.
  • T50 was not associated with CAC prevalence or incidence.

Conclusions:

  • Serum calcification propensity is associated with CAC severity and progression in CKD patients.
  • T50 may serve as a biomarker for cardiovascular risk in CKD.
  • Further research is needed to confirm these findings and explore clinical utility.
Abstract

Keywords:
Coronary artery diseasecalcification propensitycalciprotein particlescardiovascular disease (CVD)chronic kidney disease (CKD)coronary artery calcium (CAC)epidemiologyrisk factorstransformation time (T(50))

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