Related Experiment Video
Updated: Jan 27, 2026

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
Published on: May 8, 2021
Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised
Charlotte K Boughton1, Lia Bally2, Franco Martignoni2
1Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Wolfson Diabetes and Endocrine Clinic, Cambridge University Hospitals NHS Foundation Trust Cambridge, Cambridge, UK.
Fully closed-loop insulin delivery significantly improved glucose control in hospitalized patients on nutritional support. This advanced system offers a more effective treatment option compared to conventional methods.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Medical Technology
Background:
- Glucose management is complex for hospitalized patients requiring nutritional support.
- Conventional insulin therapy may be insufficient for optimal glycemic control in these individuals.
Purpose of the Study:
- To evaluate if fully closed-loop insulin delivery improves glycemic control compared to conventional subcutaneous insulin therapy.
- To assess the efficacy of closed-loop systems in inpatients receiving enteral or parenteral nutrition.
Main Methods:
- A randomized controlled trial was conducted in two centers (UK and Switzerland).
- Adult inpatients on nutritional support requiring insulin were randomized to closed-loop or conventional therapy.
- The primary endpoint was the time sensor glucose remained within the target range (5.6-10.0 mmol/L).
Main Results:
- The closed-loop group spent 68.4% of time in the target glucose range, versus 36.4% in the control group.
- This represents a significant improvement of 32.0 percentage points (p<0.0001).
- No study-related adverse events or severe hypoglycemia/hyperglycemia with ketonemia occurred in either group.
Conclusions:
- Fully closed-loop insulin delivery is an effective treatment for improving glycemic control in hospitalized patients on nutritional support.
- This technology offers a promising advancement in managing blood glucose levels for vulnerable patient populations.
More Related Videos
04:53A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
11:53The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
Published on: October 14, 2017
Related Concept Videos
Open and closed-loop control systems
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
The Roles of Bacteria and Fungi in Plant Nutrition
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Receiver Operating Characteristic Plot
Clinical Trials
There are four phases in a clinical trial. A phase one...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...