Related Experiment Video
Updated: Jan 27, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
Published on: October 30, 2015
Going Beyond the Sequences: TCR Binding Patterns at the Service of Cancer Detection
Vincent Zoete1,2,3, George Coukos4,2
1Ludwig Institute for Cancer Research - Lausanne Branch, University of Lausanne, Lausanne, Épalinges, Switzerland.
Abstract:
Deep sequencing of T-cell receptors enables the comprehensive profiling of lymphocyte populations and the characterization of the repertoire of T-cell responses against tumors, which could be applied to diagnose cancers. Ostmeyer and colleagues introduce a novel approach to characterize TCR patterns correlating with antigen recognition. By projecting the large TCR sequence space into a handful of biophysicochemical descriptors for key residues and seeking TCRs with similar antigen-binding capabilities even in the absence of identical amino acids, this approach presents several advantages over current methods.See related article by Ostmeyer et al., p. 1671.
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