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Updated: Jan 27, 2026
06:51
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
15.9K
Summary
The HDAC inhibitor entinostat combined with pembrolizumab shows good tolerability and durable responses in melanoma patients who progressed on PD-1 blockade alone. This combination offers a new treatment option for advanced melanoma.
Area of Science:
- Oncology
- Immunotherapy
- Epigenetics
Background:
- The ENCORE-601 trial investigated entinostat, an experimental histone deacetylase (HDAC) inhibitor, in combination with pembrolizumab.
- The study focused on a cohort of patients with advanced melanoma whose disease had progressed despite prior PD-1 blockade therapy.
Discussion:
- Entinostat demonstrated a favorable safety profile when administered with pembrolizumab.
- The combination therapy led to durable clinical responses in a significant portion of the patient population.
- This suggests a potential synergistic effect between HDAC inhibition and PD-1 blockade in overcoming resistance.
Key Insights:
- The combination of entinostat and pembrolizumab is well-tolerated in patients with advanced melanoma.
- Durable responses were observed in patients who had previously progressed on PD-1 inhibitors.
- Entinostat may re-sensitize tumors to PD-1 blockade, offering a new therapeutic strategy.
Outlook:
- Further investigation into the mechanisms of action and predictive biomarkers is warranted.
- This combination could represent a promising new treatment paradigm for refractory melanoma.
- Clinical development of entinostat in combination with immunotherapy is ongoing.
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