Related Experiment Video

Updated: Jan 27, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.9K

Entinostat Helps Thwart Immunotherapy Resistance

    Cancer Discovery
    |April 3, 2019
    PubMed

    Insights

    The HDAC inhibitor entinostat combined with pembrolizumab shows good tolerability and durable responses in melanoma patients who progressed on PD-1 blockade alone. This combination offers a new treatment option for advanced melanoma.

    Area of Science:

    • Oncology
    • Immunotherapy
    • Epigenetics

    Background:

    • The ENCORE-601 trial investigated entinostat, an experimental histone deacetylase (HDAC) inhibitor, in combination with pembrolizumab.
    • The study focused on a cohort of patients with advanced melanoma whose disease had progressed despite prior PD-1 blockade therapy.

    Discussion:

    • Entinostat demonstrated a favorable safety profile when administered with pembrolizumab.
    • The combination therapy led to durable clinical responses in a significant portion of the patient population.
    • This suggests a potential synergistic effect between HDAC inhibition and PD-1 blockade in overcoming resistance.

    Key Insights:

    • The combination of entinostat and pembrolizumab is well-tolerated in patients with advanced melanoma.
    • Durable responses were observed in patients who had previously progressed on PD-1 inhibitors.
    • Entinostat may re-sensitize tumors to PD-1 blockade, offering a new therapeutic strategy.

    Outlook:

    • Further investigation into the mechanisms of action and predictive biomarkers is warranted.
    • This combination could represent a promising new treatment paradigm for refractory melanoma.
    • Clinical development of entinostat in combination with immunotherapy is ongoing.

    More Related Videos

    Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model08:06

    Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

    Published on: November 26, 2010

    20.2K
    Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections16:56

    Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

    Published on: August 30, 2014

    17.5K

    Related Concept Videos

    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    1.8K
    Resistivity01:22

    Resistivity

    When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
    4.4K
    Resistance01:19

    Resistance

    When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
    5.7K
    Resistance and Conductance01:25

    Resistance and Conductance

    A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
    Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
    501
    Equivalent Resistance01:16

    Equivalent Resistance

    In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
    951
    Vascular Resistance01:20

    Vascular Resistance

    Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
    The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
    10.5K