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Updated: Jan 27, 2026

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
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Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

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Adalimumab-induced IgA nephropathy

Aneesha Kaur Bhagat Singh1,2, Andrew Sujeevan Jeyaruban3, Gregory John Wilson4

  • 1Internal Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

BMJ Case Reports
|April 3, 2019
PubMed

Immunoglobulin A nephropathy (IgAN) is the most commonly diagnosed glomerulonephritis worldwide. It is usually idiopathic and may be associated with many other diseases. Recently, biological agents including tumour necrosis factor alpha (TNFα) inhibitors have been identified as a potential cause for IgAN. We report the case of a 39-year-old woman who presented with renal dysfunction and visible haematuria. She had a background of Crohn's disease (CD) and had been on adalimumab for 4 years following a right hemicolectomy. Subsequently, she underwent a renal biopsy that demonstrated IgAN and adalimumab was ceased. Following a flare in her CD, she was commenced on infliximab, which led to remission of the IgAN and CD. This is the first case to demonstrate the occurrence of IgAN as a complication of a TNFα inhibitor (adalimumab) that remained in remission despite the commencement of a second TNFα inhibitor (infliximab).

Keywords:
crohn’s diseasedrug interactionsdrugs: gastrointestinal systeminflammatory bowel diseaseunwanted effects/adverse reactions

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