Jove
Visualize
Contact Us

Related Concept Videos

Types of Signaling Molecules01:32

Types of Signaling Molecules

12.9K
In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
12.9K
Viral Recombination00:57

Viral Recombination

25.0K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.0K
ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

4.7K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
4.7K
Types of Reports III: Telephone and Verbal Reports01:26

Types of Reports III: Telephone and Verbal Reports

1.0K
Telephone and Verbal Reports in healthcare settings are two communication methods for conveying therapeutic instructions from healthcare providers to nurses or other healthcare staff.
Here's an overview of each type:
Telephone Orders
1.0K
Viral Structure00:56

Viral Structure

74.1K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.1K
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

30.6K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
30.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms restricting hepatitis B virus cross-species transmission.

mBio·2026
Same author

EIF4H and YBX1 are essential host factors for hepatitis E virus replication and pathogenesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Receptor transporter protein 4 (RTP4)-mediated repression of hepatitis C virus replication in mouse cells.

PLoS pathogens·2025
Same author

Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice.

Journal of virology·2025
Same author

STAT1-mediated interferon signaling in the hematopoietic system is essential for restricting Usutu virus infection in vivo.

PLoS neglected tropical diseases·2025
Same author

Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine.

Nature microbiology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 27, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.8K

Decoding type I and III interferon signalling during viral infection.

Emily V Mesev1, Robert A LeDesma1, Alexander Ploss2

  • 1Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Nature Microbiology
|April 3, 2019
PubMed
Summary

Interferon (IFN) signaling is key for antiviral defense, but viruses have evolved complex ways to evade it. This review explores IFN signaling complexity, viral evasion tactics, and their impact on host tropism across species.

More Related Videos

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

14.2K
Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
09:11

Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection

Published on: July 16, 2019

9.6K

Related Experiment Videos

Last Updated: Jan 27, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.8K
Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

14.2K
Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
09:11

Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection

Published on: July 16, 2019

9.6K

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • Interferons (IFNs) are crucial for host defense against viral infections.
  • Despite numerous IFNs, only three cell surface receptors are known, indicating complex signaling pathways.
  • IFN signaling and viral evasion mechanisms create a complex, species-specific network.

Purpose of the Study:

  • To review advances in understanding differential IFN signaling inputs and outputs in antiviral defense.
  • To explore viral strategies for interfering with or circumventing host IFN defenses.
  • To address the impact of IFN signaling on host tropism and future research directions.

Main Methods:

  • Literature review of recent advances in IFN signaling and viral evasion.
  • Analysis of the interplay between host antiviral responses and viral counter-mechanisms.
  • Discussion of species-specific differences in IFN pathways and host-pathogen interactions.

Main Results:

  • Significant progress has been made in deciphering complex IFN signaling networks.
  • Viruses employ diverse strategies to evade IFN-mediated immunity.
  • IFN signaling plays an under-appreciated role in determining host tropism.

Conclusions:

  • Understanding the complexity of IFN signaling and viral evasion is critical for host defense.
  • Further research is needed to elucidate species-specific mechanisms and their impact on disease.
  • Targeting IFN pathways may offer new therapeutic strategies against viral infections.