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Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic
Marina Caskey1, Florian Klein2,3,4, Michel C Nussenzweig5,6
1Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. mcaskey@rockefeller.edu.
Abstract:
Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART interruption almost invariably leads to rebound viremia in infected individuals due to a long-lived latent reservoir of integrated proviruses. Therefore, ART must be administered on a life-long basis. Here we review recent preclinical and clinical studies suggesting that immunotherapy may be an alternative or an adjuvant to ART because, in addition to preventing new infections, anti-HIV-1 antibodies clear the virus, directly kill infected cells and produce immune complexes that can enhance host immunity to the virus.
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