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Galectin-3 as a prognostic biomarker for diabetic nephropathy
Hossam Hodeib1, Maha M Hagras1, Dina Abdelhai1
1Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Summary
Serum galectin-3 levels predict diabetic nephropathy (DN) progression in type 2 diabetes mellitus (DM) patients. Higher galectin-3 indicates increased risk for DN complications, including dialysis and death.
Area of Science:
- Nephrology
- Endocrinology
- Biomarker Research
Background:
- Diabetic nephropathy (DN) is a major cause of end-stage renal disease in type 2 diabetes mellitus (DM).
- Galectin-3 is implicated in various pathological conditions, but its role in DN is not well-established.
- Limited data exist on galectin-3 as a prognostic marker for DN.
Purpose of the Study:
- To evaluate serum galectin-3 as a novel prognostic biomarker in patients with DN.
- To assess the correlation between serum galectin-3 levels and the severity of DN.
- To determine if galectin-3 can predict DN progression.
Main Methods:
- Prospective study of 300 type 2 DM patients over three years.
- Patients categorized into normoalbuminuria, microalbuminuria, and macroalbuminuria groups based on ACR.
- Laboratory evaluation included HbA1c, creatinine, eGFR, ACR, and serum galectin-3.
Main Results:
- Mean serum galectin-3 levels were significantly elevated in macroalbuminuria patients compared to microalbuminuria and normoalbuminuria groups.
- Serum galectin-3 levels significantly predicted progression to microalbuminuria, macroalbuminuria, and dialysis.
- Galectin-3 was also a significant predictor of mortality in type 2 DM patients.
Conclusions:
- Serum galectin-3 is a significant predictor of DN progression in type 2 DM patients.
- Galectin-3 may serve as a valuable prognostic biomarker for identifying patients at high risk of DN complications.
- Further research is warranted to validate these findings in larger, multi-center studies.
Keywords:
albumin/creatinine ratiodiabetes mellitusdiabetic nephropathydialysisgalectin-3macroalbuminuriamicroalbuminuriaMore Related Videos
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