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Updated: Jan 27, 2026

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
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Chronic Fatigue Syndrome, Functional Mitochondriopathy, and Enterohepatic Dysfunction
Integrative Medicine (Encinitas, Calif.)
|April 3, 2019
Summary
Chronic fatigue syndrome (CFS) is a complex illness. Early research by Dr. Paul Cheney and colleagues in the late 1980s contributed to understanding its origins and the Functional Medicine model.
Area of Science:
- Medical Science
- Immunology
- Neurology
Background:
- Chronic fatigue syndrome (CFS) was first identified in the late 1980s.
- Initial observations linked severe fatigue to a preceding winter flu season.
- Dr. Paul Cheney and colleagues in Nevada noted this pattern in patients.
Discussion:
- The Functional Medicine model's foundational concepts were developed during 1989-1991.
- Dr. Cheney was a key contributor to these early developments.
- CFS remains a significant medical enigma.
Key Insights:
- Early CFS research focused on post-viral fatigue patterns.
- The Institute for Functional Medicine's origins are tied to CFS research.
- Functional Medicine emerged as a framework to understand complex illnesses like CFS.
Outlook:
- Further research is needed to fully understand CFS.
- Continued exploration of the Functional Medicine model may offer insights.
- Investigating the link between infections and chronic fatigue is crucial.
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