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Serum levels of periostin and exercise-induced bronchoconstriction in asthmatic children
Ju Hwan Cho1, Kyubo Kim2, Jung Won Yoon3
1Comprehensive Cancer Center, Radiation Oncology, The Ohio State University, Columbus, OH, USA.
Insights
Serum periostin levels were higher in asthmatic children with exercise-induced bronchoconstriction (EIB). Elevated periostin correlated with poorer lung function, suggesting its role as a biomarker for EIB severity in pediatric asthma.
Area of Science:
- Pediatric Pulmonology
- Biomarker Discovery
- Asthma Research
Background:
- Periostin, induced by IL-13, is a known biomarker for asthma.
- This study investigates the link between serum periostin and exercise-induced bronchoconstriction (EIB) in children with asthma.
Purpose of the Study:
- To explore the relationship between serum periostin levels and EIB in asthmatic children.
- To assess periostin as a potential indicator of EIB severity.
Main Methods:
- Study included 86 children (6-15 years), with 56 diagnosed with asthma and 30 healthy controls.
- Serum periostin levels were measured.
- Pulmonary function tests included baseline, post-bronchodilator, exercise bronchial provocation tests (BPTs), and mannitol BPTs.
Main Results:
- Asthmatic children with positive results on both exercise and mannitol BPTs showed significantly higher serum periostin levels compared to those with negative BPTs and healthy controls.
- Serum periostin levels were significantly correlated with the maximum decrease in %FEV1 and the mannitol PD15 value.
- A subset of 56 asthmatic children was categorized into four groups based on BPT outcomes.
Conclusions:
- Serum periostin levels are significantly elevated in asthmatic children exhibiting positive responses to both exercise and mannitol challenges.
- These findings support periostin's potential as a biomarker for identifying and possibly quantifying EIB severity in pediatric asthma patients.
Background:
Periostin is induced by IL-13 and has been studied as a biomarker of asthma. The present study explored the relationship between serum levels of periostin and exercise-induced bronchoconstriction (EIB) in asthmatic children.
Methods:
The study population consisted of 86 children 6-15 years old divided into an asthmatic group (n = 56) and healthy controls (n = 30). We measured the levels of periostin in serum and performed pulmonary function tests including baseline measurements, post-bronchodilator inhalation tests, exercise bronchial provocation tests (BPTs), and mannitol BPTs.
Results:
The 56 asthmatic children were divided into four groups: asthmatics with positive exercise BPT and positive mannitol BPT (n = 30), asthmatics with positive exercise BPT but negative mannitol BPT (n = 7), asthmatics with negative exercise BPT but positive mannitol BPT (n = 10), and asthmatics with negative exercise BPT and negative mannitol BPT (n = 9). Serum levels of periostin in asthmatic children with both positive exercise and mannitol BPT were significantly greater than those in asthmatic children with both negative exercise and mannitol BPT (95.0 [75.0-104.0] vs. 79.0 [68.0-82.5] ng/mL, P = 0.008) and controls (74.0 [69.75-80.0] ng/mL, P < 0.001). Periostin levels were significantly correlated with both the maximum decrease in %FEV1 and mannitol PD15 value.
Conclusion:
Serum levels of periostin in asthmatic children with both positive exercise and mannitol BPT were significantly greater than those in asthmatic children with both negative exercise and mannitol BPT and also greater than in healthy controls.
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