Partial Fanconi Syndrome Induced by Ifosfamide
Sulagna Das1, Damian N Valencia1, Adam Fershko1
1Internal Medicine, Kettering Medical Center, Dayton, USA.
Cureus
|April 3, 2019
Summary
Certain medications can cause Fanconi syndrome, a kidney tubule transport defect. Early monitoring of patients on chemotherapy is crucial to prevent severe kidney damage.
Area of Science:
- Nephrology
- Oncology
- Pharmacology
Background:
- Fanconi syndrome is a proximal renal tubule transport defect often linked to medications.
- It is characterized by metabolic acidosis and can manifest as partial or full syndrome.
- This condition is frequently underreported and missed in clinical practice.
Observation:
- A 64-year-old female with stage IV undifferentiated pleomorphic sarcoma developed severe hypokalemia, hypophosphatemia, and proteinuria after chemotherapy.
- The patient received adriamycin, ifosfamide, and mesna.
- These symptoms led to a diagnosis of partial Fanconi syndrome.
Findings:
- Chemotherapeutic agents, including ifosfamide, can induce Fanconi syndrome.
- The patient presented with key indicators of proximal tubule dysfunction.
- Diagnosis was confirmed as partial Fanconi syndrome despite absence of glycosuria.
Implications:
- Routine monitoring of renal function and electrolytes is vital for patients on nephrotoxic agents.
- Early detection of Fanconi syndrome can prevent severe renal complications.
- This case highlights the importance of vigilance in patients undergoing chemotherapy.
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