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Emerging Nano-/Microapproaches for Cancer Immunotherapy
Yu Mi1, C Tilden Hagan1, Benjamin G Vincent2
1Laboratory of Nano- and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 3, 2019
Summary
Nano-/microtechnologies enhance cancer immunotherapies like CAR-T therapy and immune checkpoint blockade. These advanced particles improve treatment efficacy and accelerate clinical translation for better cancer treatment outcomes.
Area of Science:
- Oncology
- Immunology
- Nanotechnology
Background:
- Cancer immunotherapy, including CAR-T therapy, ICB, and neoantigen vaccines, shows promise but faces challenges like low response rates and adverse events.
- Nano-/microtechnologies offer novel strategies to overcome these limitations in cancer treatment.
Purpose of the Study:
- To summarize emerging nano-/microparticle approaches in cancer immunotherapy.
- To explore how these technologies improve efficacy, elucidate immunological mechanisms, and accelerate clinical translation.
Main Methods:
- Review of recent advancements in nano-/microparticle applications for cancer vaccines.
- Analysis of nano-/microparticle-based immune checkpoint blockade strategies.
- Exploration of nano-/microparticle delivery systems for adoptive and indirect immunotherapies.
Main Results:
- Nano-/microparticles offer advantages like virus-like size, high surface-to-volume ratio, and targeted delivery for enhanced immunotherapy.
- These particles can be engineered for precise targeting and delivery of immunomodulators.
- The review highlights improved efficacy and potential for overcoming clinical hurdles in cancer immunotherapy.
Conclusions:
- Nano-/microtechnologies represent a significant advancement in improving cancer immunotherapy efficacy and safety.
- These approaches hold great potential for accelerating the clinical translation of novel cancer treatments.
- Further research into nano-/microparticle-based immunotherapies is crucial for advancing cancer care.
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