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Updated: Jan 27, 2026

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

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Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas

Donia Sadri1, Fatemeh Shahsavari1, Maliheh Hezarkhani1

  • 1Dept. of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran.

Journal of Dentistry (Shiraz, Iran)
|April 3, 2019
PubMed

Insights

Central giant cell granulomas (CGCGs) show higher microvessel density (MVD) than peripheral giant cell granulomas (PGCGs), indicating a potential vascular-proliferative nature in CGCGs. Further research is needed to explore this difference.

Area of Science:

  • Oral pathology
  • Histopathology
  • Angiogenesis research

Background:

  • Central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (PGCGs) share microscopic features but differ clinically.
  • The role of angiogenesis in these differences remains debated.

Purpose of the Study:

  • To compare microvessel density (MVD) between oral CGCGs and PGCGs.
  • Utilize CD31 and CD34 markers to assess MVD.

Main Methods:

  • Immunohistochemical staining of 18 PGCGs and 19 CGCGs using CD31 and CD34 antibodies.
  • Statistical comparison of MVD between lesion types using t-tests.

Main Results:

  • Significantly higher CD31 and CD34 expression (MVD) in CGCGs compared to PGCGs (p<0.002 and p<0.001).
  • PGCGs exhibited significant MVD differences between sexes (p<0.05), while CGCGs did not (p<0.2).

Conclusions:

  • Differences in MVD, assessed by pan-endothelial markers, suggest a vascular-proliferative component in CGCGs.
  • Further investigation is required to understand the role of vascular differences in the distinct biologic behaviors of CGCGs and PGCGs.
Abstract

Keywords:
CD31CD34Giant cell GranulomaJawPathologicAngiogenesis

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