[Immunophenotyping of lung tumors : An update]

Area of Science:

• Pathology
• Oncology
• Diagnostic Medicine

Background:

• The 2015 WHO Classification of Lung Tumors highlighted immunohistochemistry for resection specimens.
• Detailed practical guidelines for its application were previously lacking.
• This created a need for standardized recommendations in daily practice.

Purpose of the Study:

• To summarize critical questions relevant to daily practice in lung tumor diagnosis.
• To provide expert recommendations on the appropriate use of immunohistochemistry.
• To assist pathologists in the routine application of these techniques.

Main Methods:

• Convening an international expert panel.
• Identifying key questions in the daily practice of lung tumor pathology.
• Synthesizing current knowledge and expert opinion into actionable recommendations.

Main Results:

• A summary of essential aspects of immunohistochemistry in lung tumor diagnosis.
• Expert-driven recommendations addressing common challenges and uncertainties.
• Guidance for the appropriate selection and interpretation of immunohistochemical stains.

Conclusions:

• Standardized recommendations are crucial for the effective use of immunohistochemistry in lung tumor pathology.
• This expert consensus aims to improve diagnostic consistency and patient care.
• The article serves as a practical guide for the pathology community.