Related Experiment Video

Updated: Jan 26, 2026

Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion
05:30

Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion

Published on: February 14, 2025

1.5K

Putative loss of CD83 immunosuppressive activity in long-standing complication-free juvenile diabetic patients during

Ulana Juhas1, Monika Ryba-Stanisławowska2, Urszula Ławrynowicz2

  • 1Department of Medical Immunology, Laboratory of Experimental Immunology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland. ulana.juhas@gumed.edu.pl.

Immunologic Research
|April 3, 2019
PubMed

Insights

Soluble CD83 (sCD83) levels are decreased in children with long-standing type 1 diabetes (DM1), correlating with poor metabolic control. This suggests sCD83 may be a therapeutic target for chronic diabetes complications.

Area of Science:

  • Immunology
  • Endocrinology
  • Cell Biology

Background:

  • The soluble CD83 molecule (sCD83) has immunosuppressive functions and is a marker of dendritic cell differentiation.
  • Monocyte-derived cells express CD83, and their differentiation process is crucial in immune regulation.

Purpose of the Study:

  • To investigate sCD83 plasma concentration in children with type 1 diabetes (DM1).
  • To assess the relationship between sCD83 levels and monocyte differentiation into CD83+ cells in DM1 patients.
  • To explore potential therapeutic implications of sCD83 in DM1.

Main Methods:

  • Analysis of sCD83 plasma concentration in 28 newly diagnosed (ND-DM1) and 30 long-standing (LS-DM1) patients.
  • Evaluation of monocyte-derived CD83 (mCD83) expression and its regulation by TNF-α.
  • Correlation analysis between sCD83 levels, HbA1c, TNF-α, and disease duration.

Main Results:

  • Newly diagnosed DM1 patients showed high mCD83 expression, downregulated by TNF-α.
  • Monocyte differentiation into CD83+ cells was impaired in LS-DM1 patients, with dysregulated mCD83 expression.
  • LS-DM1 patients exhibited significantly decreased sCD83 plasma levels, negatively correlated with HbA1c.

Conclusions:

  • Reduced sCD83 levels in LS-DM1 patients may indicate poor metabolic control.
  • sCD83 dysregulation is linked to impaired monocyte differentiation in chronic DM1.
  • Therapeutic administration of sCD83 could represent a novel treatment strategy for chronic diabetes.

Keywords:
Membrane CD83Monocyte-derived cellsSoluble CD83Type 1 diabetes

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs05:11

Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs

Published on: May 10, 2024

1.8K

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.6K
Line Loss01:10

Line Loss

The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
535
Standing Waves01:17

Standing Waves

Sometimes waves do not seem to move; rather, they just vibrate in place. Unmoving waves can be seen on the surface of a glass of milk kept in a refrigerator, which is one example of standing waves. Vibrations from the refrigerator motor create waves on the milk that oscillate up and down but do not seem to move across the surface. These waves are formed or created by the superposition of two or more identical moving waves in opposite directions. The waves move through each other, with their...
5.4K
Standing Electromagnetic Waves01:15

Standing Electromagnetic Waves

Electromagnetic waves can be reflected; the surface of a conductor or a dielectric can act as a reflector. As electric and magnetic fields obey the superposition principle, so do electromagnetic waves. The superposition of an incident wave and a reflected electromagnetic wave produces a standing wave analogous to the standing waves created on a stretched string.
Suppose a sheet of a perfect conductor is placed in the yz-plane, and a linearly polarized electromagnetic wave traveling in the...
2.3K
Standing Waves in a Cavity01:28

Standing Waves in a Cavity

A household microwave and lasers are examples of standing electromagnetic waves in a cavity. When two conducting metal plates are placed parallel at the nodal planes, it creates a cavity where standing waves are formed. The cavity between the two planes is analogous to a stretched string held at the points x = 0 and x = L. Here, the distance 'L' between the two planes must be an integer multiple of half of the wavelength. The wavelengths that satisfy this condition are given by:
1.4K