Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Energetics of Solution Formation02:35

Energetics of Solution Formation

7.4K
The formation of a solution is an example of a spontaneous process, which is a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent...
7.4K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.0K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.0K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

15.7K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.7K
Aging01:26

Aging

659
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
659
Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

4.1K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.1K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bio-conjugated ultrabright fluorescent nanoparticles for targeted cancer-cell imaging: independent size control and brightness.

Nanoscale·2026
Same author

Development and Initial Validation of the Novel Computational Method for Dynamic Intracardiac Blood Flow Evaluation.

Diagnostics (Basel, Switzerland)·2026
Same author

<i>Caenorhabditis elegans</i> fed native gut microbiota have altered bioenergetic pathway utilization impacting mitochondrial function and susceptibility to pollutants.

Environmental science. Processes & impacts·2026
Same author

The Impact of Cardiopulmonary Bypass on the Structure and Mechanics of Red Blood Cells: Pilot Study.

Journal of clinical medicine·2026
Same author

datadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mapping.

bioRxiv : the preprint server for biology·2026
Same author

Irf5 Knockdown in Bone Marrow-Derived Macrophages Favors M1-to-M2 Transition.

Cells·2026

Related Experiment Video

Updated: Jan 26, 2026

Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field
08:54

Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field

Published on: August 27, 2021

1.8K

Cellular energetics and mitochondrial uncoupling in canine aging.

Justin W Nicholatos1, Timothy M Robinette2, Saurabh V P Tata2

  • 1Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14850, USA. jwnichol1@gmail.com.

Geroscience
|April 3, 2019
PubMed
Summary

Smaller dog breeds live longer due to enhanced mitochondrial function and thermogenesis. This study identifies key genetic regulators and cellular mechanisms contributing to canine longevity and aging diversity.

Keywords:
AgingDogsGWASMitochondriaPrimary cellsUncoupling

More Related Videos

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging
05:29

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Published on: January 17, 2025

1.8K
Preparation and Reactivity of Gasless Nanostructured Energetic Materials
09:50

Preparation and Reactivity of Gasless Nanostructured Energetic Materials

Published on: April 2, 2015

10.6K

Related Experiment Videos

Last Updated: Jan 26, 2026

Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field
08:54

Development of a Mobile Mitochondrial Physiology Laboratory for Measuring Mitochondrial Energetics in the Field

Published on: August 27, 2021

1.8K
Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging
05:29

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Published on: January 17, 2025

1.8K
Preparation and Reactivity of Gasless Nanostructured Energetic Materials
09:50

Preparation and Reactivity of Gasless Nanostructured Energetic Materials

Published on: April 2, 2015

10.6K

Area of Science:

  • Genomics
  • Comparative Biology
  • Aging Research

Background:

  • Dogs exhibit significant lifespan variation, inversely correlated with body size.
  • This variation offers a unique model for studying longevity-determining traits.
  • Over 190 dog breeds present a diverse dataset for genetic and physiological studies.

Purpose of the Study:

  • To identify novel genetic regulators associated with longevity in dogs.
  • To investigate the role of mitochondrial properties in lifespan differences between dog breeds.
  • To explore the link between thermoregulation, metabolism, and canine aging.

Main Methods:

  • Genome-wide association study (GWAS) on 4169 canines across 110 breeds.
  • Analysis of primary dermal fibroblasts from short-lived (large) and long-lived (small) breeds.
  • Mitochondrial property assessment, including respiration, uncoupling, and electron transport chain function.

Main Results:

  • Novel candidate regulators of longevity were identified through GWAS.
  • Long-lived dog breeds possess more uncoupled mitochondria with greater respiratory capacity.
  • Cells from long-lived breeds show higher catabolism and beta-oxidation rates.
  • Short-lived breeds' cells accumulate metabolites for biosynthesis and growth.

Conclusions:

  • Mitochondrial bioenergetics and thermoregulation are key factors in canine lifespan variation.
  • The uncoupled metabolic profile in long-lived breeds may enhance thermogenesis and reduce oxidative stress.
  • Cellular characteristics in long-lived breeds potentially delay age-related dysfunction and disease.