Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retina01:32

The Retina

76.2K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
76.2K
Vision01:24

Vision

59.5K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
59.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Angiopoietin-2 and vascular endothelial growth factor α inhibition by faricimab reduces pericyte-to-myofibroblast transition and the myofibroblast phenotype in vitro.

Experimental eye research·2026
Same author

Cysteinyl leukotriene receptor 1 regulates cellular glucose levels in human retinal cells.

Molecular vision·2025
Same author

Platelets regulate neural and oligodendroglial progenitors when infiltrating the brain parenchyma.

Communications biology·2025
Same author

The effect of CysLTR1 inhibition on cells of the retinal neurovascular unit in 5xFAD Alzheimer mice.

Experimental eye research·2025
Same author

Platelets During Myelin Repair in Multiple Sclerosis: Friend or Foe?

Journal of neurochemistry·2025
Same author

Modulation of the unfolded protein response with a C-terminal fragment of MANF facilitates recovery in models of multiple sclerosis.

Molecular therapy : the journal of the American Society of Gene Therapy·2025

Related Experiment Video

Updated: Jan 26, 2026

Isolation and Purification of Murine Cardiac Pericytes
10:49

Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

10.0K

Pericytes in the Retina.

Andrea Trost1, Daniela Bruckner2, Francisco J Rivera3,4

  • 1Department of Ophthalmology, University Clinic of Ophthalmology and Optometry, Research Program for Experimental Ophthalmology and Glaucoma Research, Paracelsus Medical University/SALK, Salzburg, Austria. a.zurl@salk.at.

Advances in Experimental Medicine and Biology
|April 3, 2019
PubMed
Summary

Pericytes (PCs) regulate blood vessel integrity and are crucial for tissue homeostasis. Their dysfunction is linked to CNS diseases like diabetic retinopathy, highlighting their therapeutic potential.

Keywords:
Diabetic retinopathy (DR)NG2OriginPDGFRbPericytePericyte markerRegenerationRetinaRetinopathy of prematurity (ROP)Wound healingtbx18

More Related Videos

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.5K
A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

9.0K

Related Experiment Videos

Last Updated: Jan 26, 2026

Isolation and Purification of Murine Cardiac Pericytes
10:49

Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

10.0K
Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.5K
A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

9.0K

Area of Science:

  • Vascular Biology
  • Regenerative Medicine
  • Neuroscience

Background:

  • Pericytes (PCs) are specialized cells ensheathing capillaries, vital for vascular development, blood-retina barrier (BRB) integrity, and tissue homeostasis.
  • Their contractile properties suggest roles in regulating capillary blood flow and neurovascular coupling.
  • PCs possess differentiation potential, making them candidates for regenerative medicine and tissue repair.

Purpose of the Study:

  • To provide an overview of retinal vascular development and pericyte origins.
  • To focus on the role of pericytes in retinopathy of prematurity (ROP) and diabetic retinopathy (DR).
  • To discuss animal models for studying pericyte fate and their regenerative potential.

Main Methods:

  • Literature review and synthesis of existing research on pericytes.
  • Focus on pathobiology of ROP and DR concerning pericyte involvement.
  • Exploration of animal models for pericyte research.

Main Results:

  • Pericyte dysfunction or loss is implicated in central nervous system (CNS) diseases, notably DR.
  • Retinal pericytes play critical roles in the pathogenesis of ROP and DR.
  • Animal models offer insights into pericyte behavior in disease and regeneration.

Conclusions:

  • Pericytes are key regulators of vascular health and CNS disease progression.
  • Understanding pericyte biology is essential for developing therapies for retinal vascular diseases.
  • Further research into pericyte function and regeneration holds promise for therapeutic interventions.