Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Heart01:27

Anatomy of the Heart

119.6K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
119.6K
Anatomy of the Heart01:20

Anatomy of the Heart

3.0K
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
3.0K
Overview of the Heart01:07

Overview of the Heart

13.3K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
13.3K
Conduction System of the Heart01:19

Conduction System of the Heart

12.8K
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
12.8K
Conduction System of the Heart01:20

Conduction System of the Heart

3.6K
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
3.6K
Chambers of the Heart01:16

Chambers of the Heart

10.1K
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eye Drop Development of Anti-VEGF Therapeutics by Ocular Penetrating Carrier to the Posterior Region of the Eye.

Translational vision science & technology·2026
Same author

Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy.

Science (New York, N.Y.)·2026
Same author

Cardiac pericytes function as key vasoactive cells to regulate homeostasis and disease.

FEBS open bio·2020
Same author

Cardiovascular response to small-molecule APJ activation.

JCI insight·2020
Same author

Isolation and Purification of Murine Cardiac Pericytes.

Journal of visualized experiments : JoVE·2019
Same author

Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model.

Pharmacology research & perspectives·2018
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart
07:16

Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart

Published on: July 29, 2020

6.1K

Pericytes in the Heart.

Linda L Lee1, Vishnu Chintalgattu2

  • 1Department of CardioMetabolic Disorders, Amgen Research and Discovery, Amgen Inc., South San Francisco, CA, USA.

Advances in Experimental Medicine and Biology
|April 3, 2019
PubMed
Summary
This summary is machine-generated.

Cardiac pericytes are vital mural cells in the heart, influencing cardiovascular health and disease. Understanding their biology offers new therapeutic avenues for heart repair and regeneration.

Keywords:
Cardiac pericyteCardiovascular pathophysiologyCardiovascular physiologyHeartMural cellMyocardial infarctionMyocardial ischemic diseasePerivascular cellVascular biologyVascular integrityVascular stem cellVascular tone

More Related Videos

Isolation and Purification of Murine Cardiac Pericytes
10:49

Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

10.0K
Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.5K

Related Experiment Videos

Last Updated: Jan 26, 2026

Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart
07:16

Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart

Published on: July 29, 2020

6.1K
Isolation and Purification of Murine Cardiac Pericytes
10:49

Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

10.0K
Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.5K

Area of Science:

  • Cardiovascular Biology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Pericytes are mural cells surrounding microvessels with tissue-specific roles.
  • Cardiac pericytes, though abundant in the heart, remain understudied.
  • Their emerging importance lies in cardiovascular homeostasis and dysfunction due to pleiotropism.

Purpose of the Study:

  • To highlight the critical roles of cardiac pericytes in cardiovascular health.
  • To explore their involvement in cardiac pathologies.
  • To underscore their therapeutic potential in cardiac repair.

Main Methods:

  • Literature review and synthesis of current research on cardiac pericytes.
  • Analysis of pericyte function in vascular tone, integrity, and angiogenesis.
  • Examination of pericyte involvement in myocardial infarction, fibrosis, and thrombosis.

Main Results:

  • Cardiac pericytes regulate vascular tone, integrity, and angiogenesis.
  • Pericyte dysfunction is implicated in cardiac pathologies.
  • Mesenchymal properties suggest therapeutic potential for heart regeneration.

Conclusions:

  • Cardiac pericytes are crucial for maintaining heart function.
  • Understanding their biology is key to developing novel therapeutic strategies.
  • Targeting cardiac pericytes may offer a promising cell-based therapy for cardiac diseases.