Related Experiment Video
Updated: Jan 26, 2026
07:35
The Microscopic Transcanal Approach in Stapes Surgery Revisited
Published on: February 16, 2022
2.9K
Three-factor prothrombin complex concentrates for refractory bleeding after cardiovascular surgery within an
Nazish K Hashmi1, Kamrouz Ghadimi1, Amudan J Srinivasan2
1Department of Anesthesiology & Critical Care, Divisions of Cardiothoracic Anaesthesia & Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA.
Vox Sanguinis
|April 3, 2019
Summary
Low-dose 3-factor prothrombin complex concentrate (3F-PCC) reduced blood transfusions in cardiovascular surgery patients. This approach demonstrated an acceptable rate of postoperative thrombotic complications, supporting its clinical utility.
Area of Science:
- Cardiology
- Hematology
- Transfusion Medicine
Background:
- Prothrombin complex concentrates (PCC) are used off-label for bleeding in cardiovascular surgery.
- PCC use carries a risk of postoperative thromboembolic complications.
Purpose of the Study:
- To evaluate if low-dose 3-factor PCC (3F-PCC) reduces bleeding without increasing thrombotic events.
- To assess the efficacy of a transfusion algorithm involving 3F-PCC.
Main Methods:
- Retrospective analysis of 107 complex cardiovascular surgery patients receiving low-dose 3F-PCC (20-30 IU/kg).
- Recorded allogeneic transfusions before and after PCC administration.
- Monitored for thromboembolic events within 30 days post-surgery.
Main Results:
- Mean allogeneic transfusions decreased from 12.4 to 5.0 units post-PCC (P < 0.001).
- The incidence of ischemic stroke was 3.8%, and venous thromboembolism was 6.5%.
- Median Factor II level was 87% after adherence to the algorithm.
Conclusions:
- 3F-PCC use in cardiovascular surgery effectively reduced allogeneic blood product transfusions.
- Adherence to the perioperative algorithm was linked to an acceptable rate of postoperative thrombotic/thromboembolic complications.
Related Concept Videos
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
816
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
816
01:22Bleeding in Fresh Concrete
561
Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
561
02:16Transcription Factors
82.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.4K
01:12Trial and Error and Algorithm
403
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
403
02:59Solution Concentration and Dilution
129.9K
The relative amount of a given solution component is known as its concentration. Often, though not always, a solution contains one component with a concentration that is significantly greater than that of all other components. This component is called the solvent and may be viewed as the medium in which the other components are dispersed or dissolved. Solutions in which water is the solvent are, of course, very common on our planet. A solution in which water is the solvent is called an aqueous...
129.9K
01:14Overview of the Cardiovascular System
11.3K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
11.3K