Relationships between illness representations, physical activity and depression in chronic kidney disease
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Updated: Jan 26, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Ryan Nah1, Noelle Robertson2, Faatihah A Niyi-Odumosu3
1Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.
Insights
Illness perceptions, not depression, influence physical activity in Chronic Kidney Disease (CKD) patients. Understanding how patients view their CKD can help promote physical activity and improve health outcomes.
Area of Science:
- Nephrology
- Psychology
- Public Health
Background:
- Chronic Kidney Disease (CKD) is linked to depression and high healthcare costs.
- Physical activity can mitigate CKD's adverse effects, but many patients remain inactive.
- Illness perceptions may influence physical activity levels in CKD patients.
Purpose of the Study:
- To investigate the relationship between physical activity, depression, and illness representations in non-dialysis CKD patients.
- To explore how patients' beliefs about their CKD impact their engagement in physical activity.
Main Methods:
- Cross-sectional study involving 70 non-dialysis CKD patients.
- Utilized Revised Illness Perception Questionnaire (IPQ-R), Beck Depression Inventory (BDI-II), and International Physical Activity Questionnaire (IPAQ-SF).
- Employed correlation, regression, moderation, and mediation analyses to examine relationships.
Main Results:
- Personal control over illness and timeline cyclical perceptions were significantly associated with physical activity levels.
- Depression severity did not moderate or mediate the relationship between illness representations and physical activity.
- Sixty percent of the 70 participants were male, with a mean age of 60 years.
Conclusions:
- Specific aspects of illness representations significantly correlate with physical activity in CKD patients.
- Suggests potential for psychological interventions based on illness representations to promote physical activity in CKD.
- Recommends future randomized controlled trials to evaluate such interventions.
Background:
Chronic Kidney Disease (CKD) is exacerbated by depression and confers significant healthcare costs. Whilst adverse impacts may be mitigated by physical activity, many patients with CKD remain physically inactive, with this physical inactivity potentially influenced by how CKD is appraised.
Objectives:
The study aims to explore the relationship between physical activity, depression and illness representations in CKD.
Methods:
Patients with CKD but not requiring dialysis completed the Revised Illness Perception Questionnaire (IPQ-R), Beck Depression Inventory (BDI-II) and Short-Form International Physical Activity Questionnaire (IPAQ-SF). Demographic information was obtained via medical records. Correlation and regression analyses were conducted to determine the relationship of illness representations with levels of physical activity. Moderation and mediation analyses were performed to investigate the role of depression in any relationship between illness representations and physical activity levels.
Results:
Seventy respondents, 60 % male, with a mean age of 60 ± 16 years, took part in the study. Of illness representation dimensions, personal control was positively associated with levels of physical activity whilst timeline cyclical (a subscale of the IPQ-R relating to patient beliefs about the nature of their illness) was a significant predictor. Severity of depression was neither a moderator nor a mediator of illness representations and levels of physical activity.
Conclusion:
Facets of illness representations had significant relationships with levels of physical activity. Future research concerning the development and validation of psychological interventions based on an illness representations framework for patients with CKD not requiring dialysis is proposed. The efficacy of such interventions could be then evaluated using a randomised controlled method.
Related Concept Videos
Chronic Kidney Disease I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease IV: Nursing Management
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