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Crimean Congo Hemorrhagic Fever in Eastern Turkey: Epidemiological and Clinical Evaluation
Ayşe Sağmak Tartar1, Şafak Özer Balın1, Ayhan Akbulut1
1Fırat Üniversitesi, Tıp Fakültesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Elazığ, Türkiye
Insights
This study evaluated Crimean-Congo Haemorrhagic Fever (CCHF) cases, finding most patients had tick-bite history and lived rurally. Early ribavirin treatment led to a high recovery rate, with only one fatality.
Area of Science:
- Medical Research
- Infectious Diseases
- Epidemiology
Background:
- Crimean-Congo Haemorrhagic Fever (CCHF) is a tick-borne viral illness with significant public health implications.
- Understanding the epidemiological and clinical characteristics of CCHF is crucial for effective management and prevention.
Purpose of the Study:
- To retrospectively evaluate the epidemiological and clinical findings, treatment, and prognosis of CCHF patients.
- To analyze patient demographics, exposure history, clinical presentation, and treatment outcomes.
Main Methods:
- Retrospective evaluation of 61 adult CCHF patients diagnosed between January 2011 and August 2018.
- Diagnosis confirmed by virus-specific IgM ELISA and/or viral RNA RT-PCR.
- Data collected on epidemiological factors, clinical symptoms, treatment (ribavirin), and patient outcomes.
Main Results:
- The majority of CCHF cases (67.2%) were male, with a mean age of 45.31 years.
- Most patients (98.4%) resided in rural areas, and 72.1% reported a tick-bite history.
- Fever, weakness, and loss of appetite were common symptoms; early ribavirin treatment resulted in a 98.4% recovery rate.
Conclusions:
- Tick contact history and clinical findings are vital for diagnosing CCHF, especially during peak transmission seasons (summer months).
- Public awareness campaigns and healthcare provider training are essential in endemic areas due to potential lack of known tick exposure.
- Prompt diagnosis and treatment, including ribavirin, significantly improve patient prognosis.
Objective:
The present study aimed to evaluate Crimean-Congo Haemorrhagic Fever (CCHF) in patients hospitalized in our hospital.
Methods:
A total of 61 adult patients who were diagnosed as having CCHF between January 2011 and August 2018, in whom the diagnosis was confirmed by detecting virus-specific IgM by ELISA and/or by showing viral RNA by RT-PCR and who were managed at our clinic were evaluated retrospectively for their epidemiological and clinical findings, treatment and prognosis.
Results:
Of the 61 cases, 41 (67.2%) were male and 20 (32.8%) female. The mean age of the patients was 45.31±2.12 years. Sixty (98.4%) patients were living in rural area. Forty four patients (72.1 %) had a tick-bite history. According to months, most of the cases were seen in June, July and May, respectively. Fever, weakness and loss of appetite were the most common complaints of the patients. Treatment of ribavirin was started on the day of admission in all patients. One patient who was admitted in the late period died. The other 60 patients were discharged after being healed.
Conclusions:
Especially during summers when the disease is seen frequently, the history of tick contact should be questioned and tick should be searched in the examination in the patients with suspected clinical findings. A significant number of the patients do not have a known tick contact. Therefore, training meetings should be organized about the symptoms and findings of the disease in the endemic areas and awareness should be raised among the community and the doctors working in emergency services and primary care.
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