Related Experiment Video
Updated: Jan 26, 2026
07:11
Biofilm Removal Using Carbon Dioxide Aerosols without Nitrogen Purge
Published on: November 6, 2016
6.8K
Carbon dioxide removal using low bicarbonate dialysis in rodents
Lien H Vu1, John A Kellum2, William J Federspiel3
1Division of Respiratory Medicine and Critical Care and Department of Medicine, National University of Singapore, Singapore.
Perfusion
|April 3, 2019
Summary
Bicarbonate dialysis effectively removes carbon dioxide (CO2) in animal models, matching the performance of existing extracorporeal CO2 removal methods. This finding validates in vitro results and suggests a potential new approach for managing hypercapnia.
Area of Science:
- Nephrology
- Critical Care Medicine
- Respiratory Physiology
Background:
- Extracorporeal carbon dioxide removal (ECCO2R) manages hypercapnia but is not widely available.
- In vitro studies suggest low bicarbonate dialysates can remove CO2.
- Dialysis offers a more accessible alternative for CO2 removal.
Purpose of the Study:
- To validate in vitro findings on CO2 removal using dialysis in an animal model.
- To quantify the effect of bicarbonate-free dialysis on arterial pH.
- To compare CO2 removal efficacy between conventional and bicarbonate-free dialysates.
Main Methods:
- Hypercapnic rats were dialyzed using conventional (PrismasolTM) or bicarbonate-free (Bicarb0) dialysates.
- Blood gases and electrolytes were measured to assess the impact of dialysis.
- CO2 content was measured at filter inflow and outflow.
Main Results:
- Bicarbonate-free dialysis significantly reduced partial pressure of CO2 and bicarbonate in blood compared to conventional dialysis.
- Total CO2 content in blood decreased by 459 mL/L with bicarbonate-free dialysis.
- Conventional dialysis did not significantly reduce blood CO2 content.
Conclusions:
- Bicarbonate dialysis demonstrates significant CO2 removal capabilities.
- The CO2 removal rate is comparable to existing low-flow ECCO2R systems.
- This supports the use of dialysis as a method for managing hypercapnia.
More Related Videos
Related Concept Videos
01:22Bicarbonate-Carbonic Acid Buffer
5.5K
The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:
5.5K
01:28Carbon-dioxide Fixation
688
Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
688
01:19Carbon Dioxide Transport in the Blood
4.9K
Carbon dioxide (CO2) transport in the blood is critical to human physiology. On average, our body cells produce around 200 mL of CO2 per minute, precisely the quantity expelled by the lungs. This process involves the transportation of CO2 from the tissue cells to the lungs in three primary forms.
Forms of CO2 Transport
1. Dissolved in plasma: A small percentage (7-10%) of CO2 is transported and dissolved directly in the plasma.
2. Carbaminohemoglobin: Just over 20% of CO2 is chemically bound to...
Forms of CO2 Transport
1. Dissolved in plasma: A small percentage (7-10%) of CO2 is transported and dissolved directly in the plasma.
2. Carbaminohemoglobin: Just over 20% of CO2 is chemically bound to...
4.9K
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
475
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
475
01:27Dialysis
1.3K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.3K
01:15Dialysis
1.7K
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.7K