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Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
Published on: October 16, 2016
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Immunometabolism in rheumatoid arthritis
Takaichi Okano1,2, Jun Saegusa1,2, Soshi Takahashi3
1a Clinical Laboratory , Kobe University Hospital , Kobe , Japan.
Immunological Medicine
|April 3, 2019
Summary
Cellular metabolism impacts immune cell function, particularly T cells and synoviocytes, in rheumatoid arthritis (RA). Understanding these roles, including non-metabolic functions of enzymes, may reveal new RA treatments.
Area of Science:
- Immunology
- Cellular Metabolism
- Rheumatoid Arthritis
Background:
- Cellular metabolism is crucial for immune cell function, supporting ATP production, proliferation, and differentiation.
- Immune cell subsets, like T cells, display distinct metabolic profiles essential for their roles.
- Understanding immunometabolism in rheumatoid arthritis (RA) could lead to novel therapeutic strategies.
Purpose of the Study:
- To explore the relationship between cellular metabolism and immune cell function in the context of inflammation.
- To investigate the metabolome of RA patients.
- To elucidate the non-metabolic functions of metabolic enzymes in inflammation and autoimmune arthritis.
Main Methods:
- Review of recent findings on immunometabolism.
- Analysis of the metabolome in RA patients.
- Discussion of the impact of metabolic processes on T cells and fibroblast-like synoviocytes.
Main Results:
- Metabolic enzymes have unexpected non-metabolic functions in inflammation, including roles in signaling and gene regulation.
- Metabolic processes significantly influence immune cells, particularly T cells and fibroblast-like synoviocytes, which orchestrate autoimmune arthritis.
- Specific metabolic profiles are linked to T cell subset functions.
Conclusions:
- Metabolic processes are integral to immune cell function and inflammation.
- Non-metabolic functions of metabolic enzymes represent a key area for understanding inflammatory mechanisms.
- Targeting immunometabolism holds promise for developing new treatments for rheumatoid arthritis and other chronic inflammatory diseases.
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