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Complete Genome Sequence of a Sequence Type 4846 Streptococcus pneumoniae Serotype 12F Strain Isolated from a

Bin Chang1, Masatomo Morita2, Ken-Ichi Lee2

  • 1Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan b-chang@nih.go.jp.

Microbiology Resource Announcements
|April 3, 2019
PubMed

Insights

Streptococcus pneumoniae serotype 12F rarely colonizes but causes invasive disease. This study reports the complete genome sequence of a 12F strain linked to invasive pneumococcal disease in Japan.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Streptococcus pneumoniae serotype 12F is an uncommon colonizer of the nasopharynx.
  • This serotype is frequently associated with invasive pneumococcal disease.
  • Understanding the genetic makeup of invasive strains is crucial for public health.

Purpose of the Study:

  • To report the complete genome sequence of a Streptococcus pneumoniae serotype 12F strain.
  • To analyze the genetic characteristics of a strain isolated from invasive pneumococcal disease patients.

Main Methods:

  • Whole-genome sequencing of the S. pneumoniae serotype 12F isolate.
  • Bioinformatic analysis of the obtained genome sequence.
  • Phylogenetic analysis to determine the sequence type.

Main Results:

  • The complete genome sequence of a Streptococcus pneumoniae serotype 12F strain, designated ST4846, was determined.
  • The strain was isolated from a cluster of patients with invasive pneumococcal disease in Japan.
  • The genome sequence provides a basis for understanding the genetic determinants of virulence and invasiveness.

Conclusions:

  • The availability of the complete genome sequence of this S. pneumoniae serotype 12F strain facilitates further research into its pathogenic potential.
  • This genomic data can aid in developing targeted interventions against invasive pneumococcal disease caused by this serotype.

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