Phosphine-catalyzed regiospecific (3 + 2) cyclization of 3-nitroindoles with allene esters
Li-Wen Jin1, Fei Jiang, Ke-Wei Chen
1School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 221116, China. fshi@jsnu.edu.cn guangjianM@jsnu.edu.cn furan@163.com.
Abstract:
A phosphine-catalyzed regiospecific (3 + 2) cyclization of 3-nitroindoles with allene esters has been established, which constructed indole-fused five-membered rings in good yields (up to 86%). This reaction serves as a powerful method for the construction of indole-fused five-membered rings. In addition, this reaction provides a useful strategy toward settling the challenge of utilizing other 1,3-dipoles or 1,3-dipole surrogates to perform (3 + 2) cyclizations with 3-nitroindoles in different catalytic modes, which will enrich the chemistry of nitroindoles and catalytic asymmetric dearomatization cyclizations.
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