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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Protein-Engineered Functional Materials.

Yao Wang¹, Priya Katyal¹, Jin Kim Montclare^1,2,3,4

¹Department of Chemical and Biomolecular Engineering, New York University, Tandon School of Engineering, Brooklyn, NY, 11201, USA.

Advanced Healthcare Materials

|April 3, 2019

Summary

Protein biomaterials offer versatile functions and emergent properties through advanced engineering. This review covers domain-based designs, crosslinked materials like hydrogels, and novel proteins with noncanonical amino acids.

Keywords:

biomaterials coiled-coils engineered proteins functional materials recombinant protein

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Area of Science:

Biomaterials Science
Protein Engineering
Synthetic Biology

Background:

Proteins are versatile macromolecules widely utilized as building blocks for biomaterials.
Over three decades, protein-based biomaterials have evolved significantly.
Flexibility allows proteins to be used alone or with other molecules.

Purpose of the Study:

To review protein-engineered materials.
To highlight domain-based designs and crosslinked materials, focusing on hydrogels.
To discuss engineered proteins with metal ion organization and noncanonical amino acids.

Main Methods:

Review of literature on protein-engineered materials.
Discussion of domain-based design principles.
Analysis of physical and chemical crosslinking strategies for protein hydrogels.

Main Results:

Advances in synthetic and chemical biology enable novel protein fusions and functional group integration.
Engineered proteins can be designed to organize metal ions or incorporate noncanonical amino acids (NCAAs).
These engineered proteins exhibit emergent properties for diverse applications.

Conclusions:

Protein engineering provides a powerful platform for creating advanced biomaterials.
Hydrogels represent a key application area for protein-engineered materials.
Future directions include proteins with NCAAs and metal-templating capabilities.