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Microinjection of dopamine agonists into nucleus raphe magnus affects nociception in rats
S Phillips1, R Cantrill, D Ford
1Department of Physiology, University of the Witwatersrand Medical School, Johannesburg 20001 Republic of South Africa Department of Medical Biochemistry, University of the Witwatersrand Medical School, Johannesburg 20001 Republic of South Africa.
Pain
|August 1, 1986
Abstract:
Microinjection of the dopamine receptor agonist apomorphine, and to a lesser extent dopamine itself, into the nucleus raphe magnus increased tail flick latency in conscious rats. The hypoalgesia was dependent on the integrity of catecholamine-containing pathways originating near the third ventricle and was diminished by systemic depletion of hydroxytryptamine. No simple neuronal circuitry could explain all the effects observed.