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The Role of Non-Coding RNA in Congenital Heart Diseases

Angel Dueñas1, Almudena Expósito2, Amelia Aranega3

  • 1Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain. aduenas@ujaen.es.

Journal of Cardiovascular Development and Disease
|April 4, 2019
PubMed

Insights

This review details how non-coding RNAs, like microRNAs and long non-coding RNAs, impact congenital heart diseases. Understanding these genetic and environmental factors is crucial for developing new treatments for cardiac defects.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Cardiovascular development involves intricate stages from heart tube formation to a four-chambered organ.
  • Congenital heart diseases arise from disruptions in these complex developmental processes.
  • Advances in molecular biology have significantly enhanced our understanding of cardiac morphogenesis and its genetic underpinnings.

Purpose of the Study:

  • To review the current knowledge on the role of non-coding RNAs in congenital heart diseases.
  • To highlight the specific functions of microRNAs and long non-coding RNAs in cardiac development and disease.

Main Methods:

  • Literature review of studies on non-coding RNAs and congenital heart diseases.
  • Analysis of genetic and molecular mechanisms underlying cardiac morphogenesis.
  • Synthesis of findings on the impact of environmental factors and post-transcriptional regulation.

Main Results:

  • Non-coding RNAs, including microRNAs and long non-coding RNAs, play critical roles in cardiovascular development.
  • These molecules are implicated in the pathogenesis of various congenital heart diseases.
  • Dysregulation of non-coding RNAs can arise from genetic and environmental influences.

Conclusions:

  • Non-coding RNAs represent a significant area of research in congenital heart disease.
  • Further investigation into microRNAs and long non-coding RNAs may reveal novel therapeutic targets.
  • Understanding post-transcriptional regulation is key to addressing the complexities of congenital heart defects.

Keywords:
non-coding RNA, microRNAs, lncRNAs, congenital heart disease

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