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Updated: Jan 26, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Clots retrieved by mechanical thrombectomy from acute ischemic stroke patients show no evidence of bacteria
Zenith Khashim1, Seán Fitzgerald1,2, Ramanathan Kadirvel1
1Department of Radiology, Mayo Clinic, Rochester, USA.
Background:
Bacteria and bacterial components have been associated with the activation of coagulation factors and initiating the blood clot formation. The aim of this study was to investigate whether bacterial populations are present in clots retrieved from patients that have suffered a large vessel occlusion acute ischemic stroke (AIS).
Materials And Methods:
Clot samples were collected from 20 AIS patients who underwent clot retrieval with mechanical thrombectomy. Patient clinical demographic details were noted. Expression of bacterial 16S rDNA was analyzed by standard and real-time polymerase chain reaction (PCR). Gram staining was performed to identify Gram-positive and Gram-negative bacteria.
Results:
Both the real-time and standard PCR demonstrated no expression of 16S rDNA in any of the 20 clots samples from AIS patients. Gram staining results showed no expression of Gram-positive or Gram-negative bacteria present in the clot samples.
Conclusion:
Our current study found no bacteria populations in the clots of AIS patients.
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