Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?
1Departments of Medicine,Health Research and Policy, and Biomedical Data Science,Stanford University School of Medicine; andDepartment of Statistics,Stanford University School of Humanities and Sciences; andMeta-Research Innovation Center at Stanford (METRICS),Stanford University,Stanford,CA 94305.jioannid@stanford.eduhttps://profiles.stanford.edu/john-ioannidis.
Abstract:
Neurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.
Related Concept Videos
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Higher Mental Functions of Brain: Learning and Memory
Models of Health Promotion and Illness Prevention II
The agent-host-environment model states that disease results...
Levels of Health Promotion and Illness Prevention
In primary prevention, actions taken before disease onset prevent the disease from...


