Beyond uncertainty: A broader scope for "incentive hope" mechanisms and its implications
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Updated: Aug 5, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
Published on: May 31, 2011
Omer Linkovski1, Noam Weinbach2, Shimon Edelman3
1Department of Psychiatry and Behavioral Sciences,Stanford University,Stanford,CA 94305.olinkovski@gmail.com.
Abstract:
We propose that food-related uncertainty is but one of multiple cues that predicts harsh conditions and may activate "incentive hope." An evolutionarily adaptive response to these would have been to shift to a behavioral-metabolic phenotype geared toward facing hardship. In modernity, this phenotype may lead to pathologies such as obesity and hoarding. Our perspective suggests a novel therapeutic approach.
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