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Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in

H R Wardill1, K R Secombe2, R V Bryant3

  • 1Adelaide Medical School, University of Adelaide, South Australia, Australia; Beatrix Children's Hospital, Department of Pediatric Oncology, University Medical Centre Groningen, Groningen, the Netherlands.

Ebiomedicine
|April 4, 2019
PubMed

Insights

Fecal microbiota transplantation (FMT) shows promise in cancer care, potentially protecting immunocompromised patients from infections and improving treatment outcomes. Emerging data suggest FMT can mitigate complications and support patients undergoing cancer therapy.

Area of Science:

  • Gastroenterology and Hepatology
  • Oncology
  • Microbiome Research

Background:

  • Fecal microbiota transplantation (FMT) is increasingly used for inflammatory and infectious diseases.
  • Its application in oncology is cautious due to infection risks in immunocompromised patients.

Purpose of the Study:

  • To review recent safety data of FMT in immunocompromised cancer patients.
  • To explore FMT's potential benefits in supportive oncology.

Main Methods:

  • Review of recent safety data.
  • Discussion of translational applications in oncology.

Main Results:

  • FMT may protect against bacterial translocation by diversifying the microbiome and restoring epithelial defenses.
  • FMT shows potential in preventing/treating graft-vs-host disease, sepsis, and immunotherapy-induced colitis.

Conclusions:

  • FMT appears safe and potentially beneficial in immunocompromised cancer patients.
  • FMT has emerging roles in supportive oncology, including microbiome restoration.
Keywords:
Emerging applicationsFecal microbiota transplantation (FMT)ImmunocompromisedSafetySupportive oncology

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