Related Experiment Video
Updated: Jun 24, 2026
07:16
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Introduction to the Special Issue "Neuroactive Steroids"
Alejandro F De Nicola1,2, Maria Claudia Gonzalez Deniselle3,4
1Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428, Buenos Aires, Argentina. alejandrodenicola@ibyme.conicet.gov.ar.
Cellular and Molecular Neurobiology
|April 4, 2019
Summary
Steroids significantly impact the nervous system through various mechanisms. This collection explores the molecular, physiological, and clinical effects of steroid action in the brain.
Area of Science:
- Neuroscience
- Endocrinology
- Pharmacology
Background:
- Steroids are complex molecules with diverse biological roles.
- Their influence on the nervous system is multifaceted, encompassing both established and emerging effects.
- Understanding steroid neuroactivity is crucial for both basic science and clinical applications.
Discussion:
- This volume provides a comprehensive overview of current research on steroid neurobiology.
- It covers molecular mechanisms, physiological functions, and pharmacological interventions.
- Clinical implications of steroid action in neurological disorders are also addressed.
Key Insights:
- Steroids modulate neural function at molecular and systemic levels.
- Research highlights the intricate interplay between steroids and nervous system processes.
- This work synthesizes diverse findings for a holistic understanding.
Outlook:
- Future research will likely uncover novel steroid targets and pathways in the brain.
- Further investigation into the therapeutic potential of steroids in neurological conditions is warranted.
- Continued exploration of steroid-nervous system interactions promises significant advancements.
Related Concept Videos
01:26Neurochemical Transmission: Sites of Drug Action
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
01:23Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
01:21Drugs Affecting Neurotransmitter Release or Uptake
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
01:29Drugs Affecting Neurotransmitter Synthesis
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
01:22CNS Stimulants: Psychedelic Agents
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
01:28An Overview of Psychoactive Drugs
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...