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ncRNAs associated with drug resistance and the therapy of digestive system neoplasms

Wei Feng1, Zhangyao Su2, Qingqing Yin1

  • 1Center of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.

Journal of Cellular Physiology
|April 4, 2019
PubMed

Insights

Noncoding RNAs (ncRNAs) are key players in digestive system cancer drug resistance. Understanding their mechanisms offers new therapeutic strategies to overcome treatment obstacles.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Digestive system cancers are a leading cause of cancer-related mortality globally.
  • Drug resistance significantly limits the efficacy of conventional and biological therapies for these cancers.
  • Noncoding RNAs (ncRNAs) are increasingly recognized for their role in the development and progression of cancer drug resistance.

Purpose of the Study:

  • To review the molecular mechanisms by which ncRNAs contribute to drug resistance in digestive system cancers.
  • To explore the potential of ncRNAs as therapeutic targets or agents to overcome drug resistance.

Main Methods:

  • Literature review of existing studies on ncRNAs and drug resistance in digestive system tumors.
  • Analysis of mechanisms involving ncRNA modulation of drug transporters, DNA repair, cell cycle, apoptosis, drug targets, and the tumor microenvironment.

Main Results:

  • ncRNAs influence multiple cellular pathways critical for drug response, including drug transport and cellular defense mechanisms.
  • Dysregulation of specific ncRNAs is linked to acquired resistance to various chemotherapeutic and targeted agents.
  • ncRNAs can impact the tumor microenvironment, further contributing to therapeutic challenges.

Conclusions:

  • ncRNAs represent a critical regulatory layer in the development of drug resistance in digestive system cancers.
  • Targeting ncRNAs or utilizing them therapeutically holds promise for improving treatment outcomes.
Keywords:
digestive system cancerdrug resistanceexosomeslncRNAmiRNAtherapy

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