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Related Experiment Video

Updated: Jan 26, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Doughnut Shaped Parathyroid Adenoma

Derya Çayır1, Mehmet Bozkurt1, Mehmet Erdoğan2

  • 1University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Clinic of Nuclear Medicine, Ankara, Turkey

Molecular Imaging and Radionuclide Therapy
|April 4, 2019
PubMed
Summary

A giant parathyroid adenoma presented as a thyroid nodule, causing hyperparathyroidism. Surgical removal confirmed the intra-thyroidal hemorrhagic adenoma, resolving the patient's symptoms.

Keywords:
Parathyroid adenomaTc-99m sestamibiSPECT

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Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Nuclear Medicine

Background:

  • Hyperparathyroidism is often caused by parathyroid adenomas.
  • Intra-thyroidal parathyroid adenomas can mimic thyroid nodules, complicating diagnosis.
  • Neck swelling and biochemical evidence of hyperparathyroidism (hypercalcemia, hypophosphatemia) are key indicators.

Purpose of the Study:

  • To report a rare case of a giant intra-thyroidal parathyroid adenoma presenting as a thyroid mass.
  • To highlight the diagnostic challenges and imaging findings associated with this condition.
  • To emphasize the importance of pathological confirmation after surgical intervention.

Main Methods:

  • Clinical presentation of a 52-year-old woman with neck swelling and hyperparathyroidism.
  • Diagnostic imaging including Technetium-99m MIBI ([(Tc-99m MIBI)]) scintigraphy with SPECT and cervical ultrasound.
  • Surgical management involving total thyroidectomy and parathyroid exploration.
  • Histopathological examination of the resected thyroid specimen.

Main Results:

  • Biochemical findings consistent with hyperparathyroidism: hypercalcemia and hypophosphatemia.
  • Tc-99m MIBI scintigraphy showed a "doughnut"-shaped mass with increased activity on the left side of the thyroid.
  • Cervical ultrasound revealed a mixed echoic thyroid nodule with a cystic component, without clear parathyroid abnormality.
  • Pathology confirmed a giant intra-thyroidal hemorrhagic parathyroid adenoma.

Conclusions:

  • Giant intra-thyroidal parathyroid adenomas can present as thyroid nodules and cause hyperparathyroidism.
  • Multimodality imaging, including Tc-99m MIBI scintigraphy, is crucial for localization.
  • Surgical resection and pathological evaluation are essential for definitive diagnosis and management.