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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Circulating biomarkers in chronic thromboembolic pulmonary hypertension

Meng Zhang1,2,3,4, Yunxia Zhang2,3,4, Wenyi Pang2,3,4,5

  • 11 Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.

Pulmonary Circulation
|April 4, 2019
PubMed

Insights

Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition. Identifying circulating biomarkers is crucial for early diagnosis and improved prognosis in patients with CTEPH, especially those not eligible for surgery.

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Biomarker Research

Background:

  • Chronic thromboembolic pulmonary hypertension (CTEPH) involves pulmonary vessel obstruction by organized thrombi, leading to pulmonary hypertension and right heart failure.
  • While CTEPH is potentially curable via surgery, not all patients are operable, and some face a poor prognosis.

Purpose of the Study:

  • To review recent advances in circulating biomarkers for CTEPH.
  • To discuss the importance of diagnostic and prognostic biomarkers for early intervention and improved patient outcomes.
  • To explore future applications of these biomarkers in CTEPH management.

Main Methods:

  • Literature review of recent studies on circulating biomarkers in CTEPH.
  • Analysis of identified biomarkers related to CTEPH pathomechanisms.
  • Synthesis of current knowledge and future perspectives on biomarker utility.

Main Results:

  • Several circulating biomarkers associated with CTEPH mechanisms have been identified.
  • These biomarkers show potential for both diagnosis and prognosis in CTEPH patients.
  • The existing literature on CTEPH biomarkers is limited, highlighting the need for comprehensive reviews.

Conclusions:

  • Circulating biomarkers are vital for improving the early diagnosis and prognosis of CTEPH.
  • Further research and validation of these biomarkers are essential for clinical application.
  • Biomarker discovery offers promising avenues for managing CTEPH patients, particularly non-operable cases.

Keywords:
Chronic thromboembolic pulmonary hypertension (CTEPH)biomarkerdiagnosisprognosis

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