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Visible light mediated oxidative lactonization of 2-methyl-1,1'-biaryls for the synthesis of benzocoumarins
Zhi Luo1, Zhong-Hua Gao, Zhi-Yong Song
1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn.
Organic & Biomolecular Chemistry
|April 4, 2019
Abstract:
A visible light mediated oxidative lactonization of 2-methyl-1,1'-biaryls was developed, giving benzocoumarins in good yields. The reaction features multiple C-H functionalization processes with oxygen as the final oxidant. The corresponding 2-aldehdyes, alcohols and carboxylic acids of the 1,1'-biaryls also worked well for the reaction.