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Updated: Jan 26, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

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Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review)

Xiang Shi1, Jingjing Wang1, Yu Lei1

  • 1Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.

Molecular Medicine Reports
|April 4, 2019
PubMed

Insights

The phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT) pathway regulates cell growth and proliferation. Overactivation of this pathway is linked to human cancers, making it a target for drug development in gynecological malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • The phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway is crucial for regulating cellular processes like the cell cycle, growth, and proliferation.
  • Overactivation of the PI3K/AKT pathway is a common event in human malignancies, contributing to cancer progression.
  • Targeting the PI3K/AKT pathway is a key strategy in rational drug design for cancer treatment.

Purpose of the Study:

  • To review the role and effects of the PI3K/AKT signaling pathway in specific types of gynecological cancers.
  • To highlight the significance of the PI3K/AKT pathway as a therapeutic target in gynecological oncology.

Main Methods:

  • Literature review of studies investigating the PI3K/AKT pathway in gynecological cancers.
  • Analysis of the molecular mechanisms by which PI3K/AKT signaling influences cancer development and progression.
  • Synthesis of information on the therapeutic potential of targeting this pathway.

Main Results:

  • The PI3K/AKT pathway plays a significant role in the pathogenesis of various gynecological cancers.
  • Dysregulation of PI3K/AKT signaling contributes to uncontrolled cell proliferation and survival in these cancers.
  • The pathway's involvement underscores its potential as a target for novel therapeutic interventions.

Conclusions:

  • The PI3K/AKT signaling pathway is a critical mediator in gynecological cancer progression.
  • Targeting the PI3K/AKT pathway offers a promising avenue for developing effective treatments for gynecological malignancies.
  • Further research into PI3K/AKT inhibitors is warranted for clinical application in gynecological oncology.

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