Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.0K
Bone Disorders01:29

Bone Disorders

5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
Nucleosome Remodeling02:54

Nucleosome Remodeling

10.8K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
10.8K
What is Metabolism?00:52

What is Metabolism?

131.5K
Overview
131.5K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.3K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rare Variant Association Analysis Uncovers Involvement of <i>VNN2</i> in Stroke Outcome.

Stroke·2025
Same author

Regulation of WNT16 in bone may involve upstream enhancers within CPED1.

Scientific reports·2025
Same author

Assessing the contribution of genes involved in monogenic bone disorders to the etiology of atypical femoral fractures.

Human genomics·2024
Same author

Evolutionary and functional analyses of LRP5 in archaic and extant modern humans.

Human genomics·2024
Same author

Expanding the Phenotypic Spectrum of TRAF7-Related Cardiac, Facial, and Digital Anomalies With Developmental Delay: Report of 11 New Cases and Literature Review.

Pediatric neurology·2024
Same author

Subcellular localisation of truncated MAGEL2 proteins: insight into the molecular pathology of Schaaf-Yang syndrome.

Journal of medical genetics·2024

Related Experiment Video

Updated: Jan 26, 2026

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

7.3K

Bone development and remodeling in metabolic disorders.

Jenny Serra-Vinardell1,2, Neus Roca-Ayats1, Laura De-Ugarte3,4

  • 1Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, CIBERER, IBUB, IRSJD, Barcelona, Spain.

Journal of Inherited Metabolic Disease
|April 4, 2019
PubMed
Summary
This summary is machine-generated.

Metabolic disorders can cause bone problems by affecting bone development or remodeling. Understanding these mechanisms is crucial for developing new therapies for conditions like hereditary multiple exostosis and Gaucher disease.

Keywords:
CYP1A1EXT2GGPPSGaucher diseaseatypical femoral fracturebone developmentbone remodelingmultiple hereditary exostosis

More Related Videos

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

2.2K
Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

964

Related Experiment Videos

Last Updated: Jan 26, 2026

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

7.3K
Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

2.2K
Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

964

Area of Science:

  • Endocrinology
  • Metabolic Bone Diseases
  • Skeletal Biology

Background:

  • Metabolic disorders frequently present with bone phenotypes, impacting either bone development or remodeling.
  • The underlying mechanisms of bone pathology in these diseases are often poorly understood, limiting therapeutic options.
  • Bone formation (osteogenesis) occurs during embryonic development via intramembranous or endochondral ossification, while bone remodeling is a lifelong process involving osteoblasts and osteoclasts.

Purpose of the Study:

  • To elucidate the mechanisms of impaired bone development and remodeling in metabolic diseases.
  • To highlight the clinical significance of bone phenotypes in metabolic disorders.
  • To present examples of research findings on specific metabolic bone diseases.

Main Methods:

  • Review of existing literature on metabolic bone diseases.
  • Presentation of original research findings on selected cases.
  • Analysis of bone development and remodeling processes in the context of metabolic disorders.

Main Results:

  • Hereditary multiple exostosis (osteochondromatosis) involves impaired bone development.
  • Gaucher disease affects bone remodeling processes.
  • Bisphosphonate treatment can lead to susceptibility to atypical femoral fractures, impacting bone remodeling.

Conclusions:

  • Metabolic diseases can disrupt distinct bone processes, leading to diverse skeletal pathologies.
  • Further research is needed to understand and treat bone complications in metabolic disorders.
  • Specific examples illustrate the complex interplay between metabolism and skeletal health.