Recognition and treatment of immune disorders at the time of birth

Neonatal immunology offers a fertile field for the investigator. Not only does it supply a great deal of information about immunology in general, but it also presents challenges peculiar to this critical period of life. The complement, phagocytic, antibody, and T cell systems in the neonate have characteristic defects and inadequacies. The genetic conditions that compromise the newborn's immune system are discussed in terms of clinical manifestations as well as laboratory abnormalities. In addition, patterns that may suggest the presence of immunodeficiency are described. Finally, methods of managing the immunodeficient infant are outlined, including clinical and laboratory modalities.