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Updated: Jan 26, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Developing New Analysis Functions for a Translational Research Platform: Extending the cBioPortal for Cancer Genomics
Philipp Unberath1, Christian Knell1, Hans-Ulrich Prokosch1
1Medical Informatics, University Erlangen-Nürnberg, Erlangen, Germany.
Background:
The cBioPortal is a prevalent open-source translational research platform, allowing private instances and extensions.
Objective:
Our aim was to build up an own instance of cBioPortal, identify missing functionality by interviewing researchers, and implementing these extensions.
Methods:
We examined the code base of the cBioPortal and conducted a requirements analysis with researchers. Then an own extension was implemented and a usability evaluation was performed.
Results:
We developed a new tab in the results view of cBioPortal adding the option to analyze the correlation of gene expression and mutation patterns.
Conclusion:
While extending the cBioPortal is possible, there are still some challenges to overcome. A plug-in concept and a more detailed documentation would greatly facilitate the development of own extensions.
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