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[Infections with penicillinase-producing Neisseria gonorrhoeae in females. Report on 24 cases]
Abstract:
Between the last few weeks of 1980 and March 1985 the susceptibilities of 881 strains of Neisseria gonorrhoeae to penicillin were tested by a simple screening method (disc diffusion test). 76.6% of the isolates were good susceptible, 17.7% moderately susceptible and 5.7% resistant to 3 units of penicillin G. Penicillinase-producing Neisseria gonorrhoeae (PPNG) could be detected in 24 cases (2.7%), most of them between July 1983 and January 1984 (n = 18). 23 patients have been treated successfully with oxytetracycline. All infections had been acquired in the GDR, however, the sources of infection could be firmly traced in 6 cases only. On the basis of the results some clinical and microbiological aspects of infections with penicillin resistant gonococci are discussed.
Insights
This study monitored Neisseria gonorrhoeae (gonococcus) penicillin susceptibility from 1980-1985. Penicillin resistance and penicillinase-producing Neisseria gonorrhoeae (PPNG) strains increased, necessitating alternative treatments like oxytetracycline.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Neisseria gonorrhoeae is a significant cause of sexually transmitted infections.
- Penicillin has historically been a primary treatment for gonorrhea.
- Emergence of antibiotic resistance in Neisseria gonorrhoeae poses a global health challenge.
Purpose of the Study:
- To assess the susceptibility of Neisseria gonorrhoeae strains to penicillin.
- To identify the prevalence of penicillinase-producing Neisseria gonorrhoeae (PPNG) strains.
- To evaluate treatment outcomes for penicillin-resistant gonorrhea.
Main Methods:
- Disc diffusion tests were used to determine antimicrobial susceptibility.
- 881 Neisseria gonorrhoeae isolates were tested between late 1980 and March 1985.
- Penicillinase production was screened for in resistant strains.
Main Results:
- Over 5.7% of Neisseria gonorrhoeae strains showed resistance to penicillin.
- Penicillinase-producing Neisseria gonorrhoeae (PPNG) was identified in 2.7% of cases, with a peak incidence between July 1983 and January 1984.
- Oxytetracycline proved effective in treating 23 patients with resistant gonorrhea.
Conclusions:
- A concerning trend of increasing penicillin resistance in Neisseria gonorrhoeae was observed.
- The rise of PPNG strains highlights the need for ongoing surveillance and alternative treatment strategies.
- Effective management of penicillin-resistant gonorrhea requires careful consideration of antibiotic susceptibility patterns.