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Updated: Jan 26, 2026
07:40
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
Published on: June 29, 2016
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Randomized Clinical Study Comparing Three Experimental Denture Adhesives and Fixodent® versus No Adhesive
Alyson Axe1, Ritika Jain1, Roshan Varghese1
1GSK Consumer Healthcare, Weybridge, Surrey, UK.
The Journal of Clinical Dentistry
|April 4, 2019
Summary
Denture adhesives significantly improve bite force in well-fitting dentures compared to no adhesive. Experimental and positive control adhesives enhanced denture function over 12 hours.
Area of Science:
- Dental materials science
- Prosthodontics
- Biomechanical engineering
Background:
- Denture adhesives enhance denture performance, including stability and bite force.
- Optimizing denture adhesive formulations is crucial for improving patient quality of life.
Purpose of the Study:
- To compare the efficacy of three novel denture adhesives against a positive control and a no-adhesive condition.
- To evaluate the impact of denture adhesives on incisal bite force over a 12-hour period.
Main Methods:
- A single-center, randomized, examiner-blind, crossover clinical study.
- 48 subjects with moderately well- to well-fitting maxillary dentures participated.
- Incisal bite force was measured electronically at multiple time points up to 12 hours post-application.
Main Results:
- All tested denture adhesives significantly increased bite force compared to the no-adhesive group.
- Adhesive 2 showed no significant difference compared to the positive control.
- Adhesive 1 and Adhesive 3 demonstrated statistically significant improvements, though generally less than the positive control.
Conclusions:
- Denture adhesives provide statistically significant improvements in bite force for individuals with well-fitting dentures.
- All evaluated denture adhesives were well-tolerated by study participants.
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