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Novel Quinolylnitrones Combining Neuroprotective and Antioxidant Properties
Mourad Chioua1, Manuel Salgado-Ramos1,2, Daniel Diez-Iriepa1
1Institute of General Organic Chemistry (CSIC) , Juan de la Cierva 3 , Madrid 28006 , Spain.
Abstract:
We describe here the preparation, neuroprotective analysis, and antioxidant capacity of 11 novel quinolylnitrones (QN). The neuroprotective analysis of QN1-11 in an oxygen-glucose deprivation model, in primary neuronal cultures, has been determined, allowing us to identify QN6 as a very potent neuroprotective agent, showing significant high value at 0.5 and 10 μM (86.2%), a result in good agreement with the observed strong hydroxyl radical scavenger of QN6.
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