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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Antiplasmodial Diterpenoids from Psiadia arguta
Keshika Mahadeo1, Gaëtan Herbette2, Isabelle Grondin1
1Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies , Université de la Réunion , 15 Avenue René Cassin, CS 92 003 , 97 744 St Denis Cedex 9 , La Réunion , France.
Abstract:
An ethyl acetate extract of Psiadia arguta leaves showed in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values of 12.3 ± 2.4 μg/mL (3D7 strain) and 13.5 ± 3.4 μg/mL (W2 strain). Phytochemical investigation led to the isolation and characterization of 16 compounds including four new diterpenoids: labdan-8α-ol-15-yl-(formate) (1), labdan-8α-ol-15-yl-(2-methylbutanoate) (2), labdan-8α-ol-15-yl-(3-methylpentanoate) (3), and labdan-8α-ol-15-yl-(labdanolate) (4). The latter compounds were characterized by spectroscopic methods (1D and 2D NMR, HRMS, and IR). The in vitro antiplasmodial activities of all compounds were evaluated. The known compounds labdan-13( E)-en-8α-ol-15-yl acetate (5), labdan-8α-ol-15-yl acetate (6), 13- epi-sclareol (7), labdan-13( E)-ene-8α,15-diol (8), and (8 R,13 S)-labdane-8α,15-diol (9) exhibited antiplasmodial effects, with IC50 values of 29.1, 33.2, 35.0, 36.6, and 22.2 μM, respectively.
