GenDiS database update with improved approach and features to recognize homologous sequences of protein domain

Meenakshi S Iyer1, Kartik Bhargava1,2, Murugavel Pavalam1

  • 1National Centre for Biological Sciences, Tata Institute of Fundamental Research (TIFR), Gandhi Krishi, Vignana Kendra Campus, Bellary Road, Bangalore, Karnataka, India.

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Conservation of Protein Domains Over Different Proteins02:26

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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