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Published on: October 2, 2020
Predilution On-Line Hemodiafiltration Improves Albumin Redox in Maintenance Hemodialysis Patients
Takeshi Shigematsu1, Takahiro Kuragano2, Takenobu Kamimura1
1Heiseikai Miyamoto Clinic, Nishinomiya, Japan.
Background/Aim:
In this study, we compared the dialysis efficiency, oxidative stress, and nutritional conditions between predilution on-line hemodiafiltration (pre-OL-HDF) and conventional hemodialysis (HD) using a super-flux dialyzer (CHD).
Method:
This was a crossover study of 38 maintenance HD patients. All patients were treated with CHD for the first 4 months (1st CHD period), then were switched to pre-OL-HDF for 4 months (pre-OL-HDF period), and were returned to CHD for the next 4 months (2nd CHD period).
Results:
We found no significant difference in the removal ratio of small uremic substances or the indices of inflammation or nutritional states between the pre-OL-HDF and CHD periods. However, we found higher removal of β2 micro-globulin in the pre-OL-HDF period, and the human mercapto-albumin (Alb)/human serum Alb ratio was significantly higher in the pre-OL-HDF period.
Conclusion:
Treatment with pre-OL-HDF enabled enhanced removal of middle molecule uremic toxins and better Alb redox than did CHD.
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